Another grim reason to avoid e-cigarettes — and it has nothing to do with lung disease

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There’s more evidence that e-cigarette may be bad for your health.

Smoking e-cigarettes increases the risk of heart disease — elevating bad cholesterol, triglycerides and glucose levels, and decreasing blood flow in the heart — and is also associated with coronary vascular dysfunction, according to two separate studies that will be presented at the American Heart Association’s Scientific Sessions, an annual meeting focused on shaping the future of cardiovascular science and medicine, in Philadelphia from Nov. 16 to Nov. 18.

Bad cholesterol was higher in people who only smoked e-cigarettes compared to nonsmokers.

Over 2,000 Americans who use e-cigarettes have become sick since March, many of them teenagers and young adults, and at least 40 people have died. The bulk of the cases occurred in August and September but new cases are still being reported, the Associated Press reported. Inhaling tiny droplets of Vitamin E acetate, used to thicken vaping fluid, has only recently been used as a thickener in vaping fluid, can be harmful, previous studies have suggested.

“There is no long-term safety data on e-cigarettes,” said Rose Marie Robertson, the American Heart Association’s deputy chief science and medical officer. “However, there are decades of data for the safety of other nicotine replacement therapies.” Bad cholesterol, or low-density lipoproteins, was higher in sole e-cigarette users compared to nonsmokers. (Juul did not respond to a MarketWatch request for comment.)

Researchers evaluated healthy adults (ages 21 to 45) without existing cardiovascular disease and taking no daily medications. The study’s 476 participants included 94 non-smokers, 45 e-cigarette smokers, 52 e-cigarette and tobacco cigarette smokers; and 285 tobacco cigarette smokers. Analysis was adjusted for age, race, sex, and non-smokers, and whether people smoked traditional and/or e-cigarettes.

“The best option is to use FDA-approved methods to aid in smoking cessation, along with behavioral counseling,” said the study’s author Sana Majid, a postdoctoral fellow in vascular biology at the Boston University School of Medicine. The American Heart Association Tobacco Center for Regulatory Science provided research materials for the study, and it was funded by The National Heart, Lung, and Blood Institute and the FDA Center for Tobacco Products.

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In a separate study to be released at the same conference this week, researchers analyzed heart blood flow, a measure of coronary vascular function, of 19 young adult smokers (ages 24 to 32) immediately before and after smoking either e-cigarettes or tobacco cigarettes. They examined coronary vascular function while participants were at rest and after performing a hand-grip exercise to simulate physiologic stress.

These studies could be worrying news for e-cigarette users, especially those who are starting young.

This could be worrying news for e-cigarette users, especially those who are starting young. Nearly 28% of high schoolers and 11% of middle schoolers this year reported e-cigarette use within the past 30 days, a National Youth Tobacco Survey concluded. More than half of those current e-cigarette users said that Juul was their usual brand, according to the research, which was funded by the Food and Drug Administration and the Centers for Disease Control and Prevention.

Among many claims in a recent wrongful-termination lawsuit filed by a former Juul executive — Siddharth Breja, the company’s former senior vice president of finance — was the allegation that company leadership had known that mint-flavored pods would compensate for a lack of sales from other flavors. Juul announced earlier this month that it would stop selling mint e-cigarettes; it previously said it would stop selling fruit and dessert flavors.

Juul previously told CNBC the company would “vigorously defend this lawsuit” and dismissed its allegations as “baseless.” The new research comes as the CDC continues to investigate deaths and a lung-injury outbreak related to vaping. Some 1,888 cases have been reported from Washington, D.C. and every U.S. state except for Alaska as of Oct. 29, while 37 deaths across 24 states have been confirmed.

The CDC recommends that people should not purchase any type of e-cigarette or vaping, or products containing THC — the component in marijuana that causes psychoactive effects — off the street. “Since the specific compound or ingredient causing lung injury are not yet known, the only way to assure that you are not at risk while the investigation continues is to consider refraining from use of all e-cigarette or vaping products,” it said.

(Meera Jagannathan contributed to this story.)